Next-generation snakebite therapy
Using a plethora of tools in molecular biology, transcriptomics, proteomics, bioinformatics and several other inter-disciplinary fields, this project attempts to unravel the biochemical complexity of venoms of the medically-relevant snake species in India, and to design recombinant antivenoms with unparalleled efficacy and cross-neutralizing capabilities for treating India’s tens of thousands of annual snakebite victims.
Efficient antivenoms for the 'big four' Indian snakes
Beyond the 'big four' prevail the 'neglected many'
Genomics of venomous animals
By sequencing the genomes of venomous animals (snakes, venomous mammals, etc.), we are investigating the origin and evolution of both toxin and non-toxin protein coding gene families that underpin adaptations of these enigmatic animals.
Evolution stings: evolution of hymenopteran venoms
This project focuses on understanding the diversification of venom in Hymenoptera (Wasps, Bees and Ants) and its role in the evolutionary success of this lineage.
Unraveling the biochemical complexity and evolution of neglected scorpion lineages
Molecular evolution of animal venoms
Venom encoding genes are theorized to have originated from physiological protein coding genes; i.e. proteins that perform physiological roles. But the genetic and evolutionary mechanisms that underpin the recruitment of these 'non-toxic' proteins into venom function remain unexplored. Using next-generation 'omics' and bioinformatics tools, this project is investigating some of the mechanisms that have facilitated the origin, diversification and the molecular evolution of venom proteins.